Capture and quantitatively prioritize patient, clinician and other stakeholder preferences to design multi-dimensional endpoints using Net Treatment Benefit (NTB).
Integrate outcomes that matter most to patients, clinicians, regulators and sponsors into a single, prioritized treatment assessment for patient-centric clinical trial design.
Design clinical trials around what matters most
Traditional clinical trials often rely on endpoints that fail to capture the full patient experience. One2Treat Voice enables sponsors to systematically capture and prioritize outcomes that matter most to patients and other stakeholders.
These preferences are integrated into a multi-dimensional endpoint using Net Treatment Benefit (NTB), creating a patient-centric approach to clinical trial design that reflects efficacy, safety, tolerability and quality of life within a single treatment assessment.
As a result, sponsors can design patient-centric clinical trials that are more relevant to patients, more statistically efficient, and better aligned with regulatory, HTA and market access requirements.
- Patient-centric clinical trial design: Ensure clinical trials reflect outcomes that matter most to patients and stakeholders, improving the relevance and impact of treatment assessments
- Improved statistical efficiency: Integrating multiple prioritized outcomes into a single endpoint can increase statistical power and reduce required sample sizes
- Faster development: Smaller, more efficient trials can shorten recruitment timelines and accelerate clinical development
- Lower development costs: Reduced sample sizes and shorter timelines help sponsors optimize clinical trial budgets
By aligning endpoints with stakeholder priorities and applying an integrated analysis, One2Treat makes trial design more efficient, meaningful, and impactful.
** OSE Immunotherapeutics and One2Treat jointly won the Innovation award for Endpoint Design in the 2025 Clinical Trials Arena Excellence Awards. **
Quantify what matters most to patients and stakeholders
One2Treat Voice is a software solution that enables patients, clinicians, regulators and clinical trial sponsors to quantitatively express and prioritize the outcomes they consider most meaningful.
Through a structured and transparent process, these preferences are translated into a hierarchy of clinical outcomes that forms the basis of a multi-dimensional endpoint using Net Treatment Benefit (NTB).
Consequently, sponsors can design patient-centric clinical trials that better reflect stakeholder priorities while generating robust evidence for regulatory, HTA and market access decision-making.
Business Cases
